药物动力学和药效动力学结合在抗菌药物研发和临床治疗中的应用

J SHI - 中国临床药理学与治疗学, 2007 - manu41.magtech.com.cn
… of antibacterial PK-PD and model based antibacterial drugpharmacokinetics ;pharmacodynamics
; antibacterial ;in vitro … monplace which has led to the prediction that we are reentering …

[HTML][HTML] 美罗培南不同给药方案有效性与耐药风险的蒙特卡洛模拟

邹雅敏, 张迪, 董亚琳 - 医药导报, 2021 - yydbzz.com
… the prediction performance of the published population pharmacokinetic models for meropenem
in critically ill … infusion of antimicrobial therapy versus intermittent infusion therapy in the …

[HTML][HTML] 多粘菌素临床应用与困局

黄晨, 肖永红 - 医药导报, 2020 - yydbzz.com
pharmacokinetic data to guide dosing in critically ill patients. … predicts colistin efficacy and
(ii) determine the values for the … a reliable antimicrobial drug, but only as salvage therapy, for …

[HTML][HTML] 特殊患者使用替加环素的药动学研究进展

封永莉, 边原, 陈璐, 李慧, 舒永全, 张丽娟 - 医药导报, 2020 - yydbzz.com
… affect the safety and efficacy of medication.This article focuses … new antibacterial based on
in vitro and pharmacokinetic/… )/clearance to enable data prediction in morbid obesity subjects; (…

[PDF][PDF] 药物治疗领域Ⅰ: 中枢神经系统和疼痛

JB Taylor, JT David - 2006 - ecsponline.com
… Volume 3 (edited by Hugo Kubinyi) critically reviews the … the assessment of the pharmacokinetic
(absorption, distribution, … in vitro and in vivo, in reviving the fortunes of the drug discovery …

[PDF][PDF] 药物治疗领域Ⅱ: 代谢综合征, 泌尿生殖系统, 胃肠道和心血管系统

JB Taylor, JT David - 2006 - ecsponline.com
… Volume 3 (edited by Hugo Kubinyi) critically reviews the … the assessment of the pharmacokinetic
(absorption, distribution, … in vitro and in vivo, in reviving the fortunes of the drug discovery …

[HTML][HTML] 替加环素临床应用剖析

肖婷婷, 肖永红 - 医药导报, 2019 - yydbzz.com
… of different empirical antimicrobial therapies on the survival … The aim of this study was to
assess the pharmacokinetic (PK) … trial predicted that a dosage of 1.2 mg/kg q12h would lead to …

[PDF][PDF] 多黏菌素E 对重症患者的有效性及安全性分析: 一项基于蒙特卡罗模拟的体外研究

潘爱军, 梅清, 杨田军, 高晓览, 鲁怀伟, 叶英… - 中华危重病急救 …, 2017 - cccm-em120.com
… fAUC/MIC is the most predictive pharmacokinetic/pharmacodynamic index of colistin … The
analysis of drug resistance phenotype and in vitro antimicrobial agent combination activity

[HTML][HTML] 万古霉素在重症感染患者的药动学

黄兴富, 童伟, 吴静, 陈虹, 黄洁, 方洁 - 医药导报, 2018 - yydbzz.com
… In this review, we analyse the typical patterns of antimicrobial … , which uses
pharmacokinetic/pharmacodynamic derived models from critically ill patients to predict accurately the …

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P Bloom - 2013 - mediskin.cn
… frequency of multidrug resistance complicates the selection of antimicrobial therapy. … MRSP
in vitro (Weese et al., 2012). Whether miconazole proves to have the same in vivo effect is …